The physical microbe : an introduction to noise, control, and communication in the prokaryotic cell / Stephen J. Hagen.
Τύπος υλικού:
ΚείμενοΣειρά: IOP concise physicsΛεπτομέρειες δημοσίευσης: San Rafael [Καλιφόρνια] : Morgan & Claypool Publishers, c2017.Περιγραφή: 1 ηλεκτρονική πηγή (ποικίλες σελιδαριθμήσεις) : εικ. (μερ. έγχρ.)ISBN: - 9781681745299
- 9781681745312
- Introduction to noise, control, and communication in the prokaryotic cell
- 579.3 23
Περιλαμβάνει βιβλιογραφικές παραπομπές.
Preface : why the physical microbe? -- 1. Introduction -- 1.1. Diversity -- 1.2. Size -- 1.3. Energy -- 1.4. Food -- 1.5. Diffusion versus size
2. Growth -- 2.1. Exponential growth -- 2.2. Stationary phase -- 2.3. Lag phase and decline -- 2.4. Balanced growth -- 2.5. Partitioning of resources -- 2.6. Individual cells in balanced growth
3. Gene regulatory networks -- 3.1. Transcription and translation -- 3.2. Representation of networks and pathways -- 3.3. Gene regulation basics -- 3.4. Deterministic models for gene regulation
4. Stochastic gene expression -- 4.1. Variability at low copy number -- 4.2. Modeling stochastic expression -- 4.3. Bursts of gene expression -- 4.4. Protein distributions with both transcription and translation -- 4.5. Intrinsic and extrinsic noise -- 4.6. Noise reduction and stability through feedback
5. Phenotypic switching -- 5.1. Two types of persisters -- 5.2. Toxin-antitoxin systems and HipBA -- 5.3. Bet-hedging by phenotypic switching
6. Communication -- 6.1. Chemical communication -- 6.2. Pheromone triggered transitions of nonlinear systems -- 6.3. Electrical communication
7. Bacillus subtilis competence and sporulation : the final exam -- 7.1. Competence decision by noisy autofeedback -- 7.2. Phosphorelay sensor for sporulation -- 7.3. A mutually repressing circuit inhibits competence -- 7.4. Input from intercellular communication.
Physical biology is a fusion of biology and physics. This book narrows down the scope of physical biology by focusing on the microbial cell; exploring the physical phenomena of noise, feedback, and variability that arise in the cellular information-processing circuits used by bacteria. It looks at the microbe from a physics perspective, asking how the cell optimizes its function to live within the constraints of physics. It introduces a physical and information-based (as opposed to microbiological) perspective on communication and signalling between microbes.
