Cancer metastasis : related genes / edited by Danny R. Welch.

Includes bibliographical references and index.

Preface -- 1. Metastasis-Suppressor Genes: A Review and Perspective on an Emerging Field -- 2. The Roles of Map Kinases in Controlling Cancer Metastasis -- 3. Tumor Metastasis-associated Human Mta1 Gene: Role in Epithelial Cancer Cell Proliferation and Regulation -- 4. Cooperative Integrin Interactions in the Regulation of Tumor Metastasis -- 5. Brain Metastasis Associated Genes -- 6. Autocrine Motility Factor and its Receptor as Regulators of Metastasis -- 7. nm23 Metastasis Suppressor Gene -- 8. Gene Regulation in Melanoma Metastatis -- 9. Heterochromatin-associated Protein 1, HP1Hsalpha, in Breast Cancer Invasion and Metastasis -- 10. Inhibition of Invasion and Metastasis During Specific Amino Acid Restriction Associated with Metastasis Suppressor and Other Gene Changes -- 11. Role of BRMS1 in Breast Carcinoma Metastasis -- 12. The Role of KISS1 in Melanoma Metastasis Suppression -- 13. Osteopontin: a Ras-regulated Gene That Contributes to Tumor Metastasis -- 14. The Emerging Role for the mRNA Cap-binding Protein, EIF-4E, in Metastatic Progression -- Index.

This volume is the first attempt to summarize current knowledge about the underlying molecular and biochemical mechanisms controlling the metastatic phenotype. While all previous authors attempted to put their findings into a context for translation to the clinical situation, the state of the art does not fully allow this because the field of metastasis is relatively new. Nonetheless, the contents of this volume will be of use to members of the cancer research community and clinicians interested in developing and implementing novel forms of treatment for cancer.