Photomedicine and stem cells : the Janus face of photodynamic therapy (PDT) to kill cancer stem cells, and photobiomodulation (PBM) to stimulate normal stem cells / Heidi Abrahamse, Michael R. Hamblin.

Περιλαμβάνει βιβλιογραφικές παραπομπές.

1. Introduction -- 1.1. The Janus face of photomedicine -- 1.2. Photodynamic therapy--the killer -- 1.3. Cellular effects of PDT -- 1.4. Photobiomodulation--the healer

2. Cancer stem cells -- 2.1. Evidence for the existence of CSCs and their characteristic markers -- 2.2. Role in tumor recurrence -- 2.3. Anti-CSC approaches

3. PDT and cancer stem cells -- 3.1. PDT and cancer treatment -- 3.2. PDT and CSCs -- 3.3. ABC transporters and ABCG2 -- 3.4. ABCG2 in cancer stem cells -- 3.5. ABCG2 and PS efflux -- 3.6. Efflux pump inhibition and PDT -- 3.7. Evidence of effect of PBM on CSCs

4. Normal stem cells -- 4.1. Developmental biology -- 4.2. Markers and phenotypes -- 4.3. Stem cell niches -- 4.4. Asymmetric and symmetric stem cell division -- 4.5. Differentiation programs -- 4.6. Stem cell therapies

5. PBM and stem cells -- 5.1. Introduction -- 5.2. Mechanisms of PBM/LLLT -- 5.3. Why should PBM particularly affect stem cells? -- 5.4. Role of stem/progenitor cells in PBM/LLLT -- 5.5. PBM to the bone marrow

6. PBM and adipose-derived mesenchymal stem cells -- 6.1. Adipose-derived stem cells -- 6.2. PBM and ADSCs -- 6.3. Studies from the Abrahamse laboratory -- 6.4. Work from the Hamblin laboratory

7. PBM and dental stem cells -- 7.1. Introduction -- 7.2. PBM and dental stem cells -- 7.3. PBM and tooth regeneration -- 7.4. TGF-gbs mediates PBM induction of dentin repair in vivo -- 7.5. Conclusion

8. The role of stem cells and progenitor cells in PBM for brain disorders -- 8.1. Introduction -- 8.2. PBM and the brain -- 8.3. PBM for stroke -- 8.4. PBM for traumatic brain injury -- 8.5. PBM/LLLT for other brain disorders -- 8.6. Conclusion

9. PBM and stem cells in hair regrowth -- 9.1. Introduction to hair growth -- 9.2. Skin, hair follicles, and stem cells -- 9.3. Alopecia -- 9.4. PBM for alopecia -- 10. Conclusion.

Janus, the ancient Roman god depicted with two faces is an appropriate metaphor for light therapy. In the right photodynamic therapy conditions, light is able to kill nearly anything that is living such as cancers, microorganisms, parasites, and more. On the opposite face, light of the correct wavelength and proper dose (photobiomodulation) can heal, regenerate, protect, revitalize and restore any kind of dead, damaged, stressed, dying, degenerating cells, tissue, or organ system. This book discusses both sides of Janus' face in regards to light therapy.